CS Seminar: Modelling of the Xenopus tadpole spinal cord

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CS Seminar: Modelling of the Xenopus tadpole spinal cord

Postby J. Borg » Fri Oct 14, 2016 12:03 pm

WEDNESDAY 19TH OCTOBER, 2:30PM, CR08 (Turing Lab, Colin Reeves Building)

Tea, Coffee and Biscuits available before, during and after the seminar

"Computational modelling of the Xenopus tadpole spinal cord: Biologically realistic models of connectivity and functionality"
Prof. Roman Borisyuk, School of Computing, Electronic and Mathematics - Plymouth University

In close collaboration with neurobiologists from the University of Bristol (Alan Roberts and Steve Soffe) we have developed a new computational method to define synaptic connectivity (in the form of a “connectome”) between neurons in the tadpole spinal cord. The connectome is generated by a “developmental” process where the growing axons intersect dendrites and create connections. The resulting network has around 1,500 neurons with around 100,000 connections, and its statistical properties are similar to experimental measurements. We have developed a functional network model of spiking (Hodgkin-Huxley type) neurons and used the generated connectome to produce a pattern of neural activity. Remarkably, the generated activity is very stable and corresponds with the typical pattern seen in vivo during fictive swimming (anti-phase oscillations between left and right sides of the body). These results are in a good agreement with experimental study of swimming patterns in the tadpole spinal cord.
J. Borg
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