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Biostatistics Group Seminar Tue 7th May

PostPosted: Wed Apr 17, 2019 6:34 pm
by rsc97
Biostatistics Group Seminar Series
Research Institute for Primary Care and Health Sciences
Keele University

Title: The Times They Are A-Daptive: Towards More Efficient Clinical Trials
Speaker: Dr Philip Pallman, Cardiff University
Date: Tuesday 7th May 13:00-14:00

Venue: Dinwoodie Lecture Theatre, David Weatherall Building
https://www.keele.ac.uk/connect/howtofi ... colour.pdf

Abstract: Adaptive methods enhance the flexibility of clinical trial designs as they allow for design changes based on accumulating data while ensuring the validity and integrity of the trial. Adaptations like sample size reassessment or early stopping can lead to very efficient and also more ethical trials. Adaptive designs are applicable throughout the clinical development process, from early-phase dose finding (e.g., continual reassessment method) to confirmatory trials in later phases (e.g., multi-arm multi-stage designs).
We give an overview of available adaptive methods that are potentially useful for trials the CTU is currently planning, presented in a non-technical way that appeals to all involved in clinical trials. We show examples of actual adaptive trials, and highlight some practical challenges of adaptive designs and how they can be overcome. There will be plenty of time for questions and discussion. Our whistle-stop tour includes key issues around funding, trial conduct, communication with stakeholders and trial participants, risks of introducing bias, interpretation of results, and reporting of findings using a recently developed CONSORT extension. This is followed by a highly interactive session where we discuss in small groups various design aspects and their practical implications and potential pitfalls, based on an example of a current NIHR-funded confirmatory trial with a novel adaptive design.