Biostatistics Group Seminar, Tue 9th July

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Biostatistics Group Seminar, Tue 9th July

Postby rsc97 » Thu Jun 06, 2019 6:00 pm

Biostatistics Group Seminar
Research Institute for Primary Care and Health Sciences
Keele University

Title: Multi-state modelling: An Overview
Speaker: Dr Andrew Titman, Lancaster University.
Date: Tuesday 9th July 12:00-13:30
Venue: Dinwoodie Lecture Theatre, David Weatherall Building

Abstract: Multi-state modelling is a technique within event history analysis. Such models are particularly useful for the joint modelling of survival and important ordinal or categorical time dependent covariates. For instance, they have been used extensively to model chronic diseases, where interest may lie both in the rate of progression between clinically defined stages of disease and in the effect of progression on the hazard of death.
The talk will give an overview of the principal methods and key assumptions used in multi-state models. A distinction will be made between continuously observed processes, where much of the machinery from standard survival analysis carries across and there is an emphasis on non- or semi-parametric methods, and interval-censored or panel-observed data where there are additional computational challenges and analysis is usually parametric. The methods will be illustrated through applications such as modelling progression-free and overall survival in cancer studies and modelling the onset of cardiac allograft vasculopathy in post-heart-transplantation patients.
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