Biostatistics Group Seminar, Thursday 5th December

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Biostatistics Group Seminar, Thursday 5th December

Postby rsc97 » Mon Nov 25, 2019 8:55 pm

Biostatistics Group Seminar
School of Primary, Community and Social Care
Keele University

Title: Treatment effect and time effect heterogeneity in stepped-wedge cluster randomised trials
Authors: James Martin and Karla Hemming
Speaker: James Martin, Institute of Applied Health Research, University of Birmingham, UK

Date: Thursday 5th December 12:00-13:00

Venue: Dinwoodie Lecture Theatre, David Weatherall Building ... colour.pdf

Abstract: In a standard parallel cluster randomised trial, the effect of time is balanced across intervention and control arms. In a stepped-wedge cluster randomised trial (SW-CRT), calendar time is associated with the intervention exposure and potentially the outcome. Standard methods to estimate the power in a SW-CRT assume that the underlying time trend is consistent across all clusters, and that the observed treatment effect is uniform across all clusters. Increasingly, SW-CRTs are being conducted across multiple countries or across other settings where these assumptions are expected to be violated.
We begin by outlining the different cluster randomised trial designs, and discuss why time trends are important in a stepped-wedge trial design. Through the use of a recently conducted study, we illustrate potential approaches for evaluating a SW-CRT with treatment effect and time effect heterogeneity across clusters, and discuss the implications of using standard methods.
We discuss approaches that could be used to help design future trials that allow for strata or cluster specific secular trends and strata or cluster specific intervention effects.
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